All Those Drug-Likeness Papers: A Bit Too Neat to be True?

There's a fascinating paper out on the concept of "drug-likeness" that I think every medicinal chemist should have a look at. It would be hard to count the number of publications on this topic over the last ten years or so, but what if we've been kidding ourselves about some of the main points? The big concept in this area is, of course, Lipinski criteria, or Rule of Five. Here's what...